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Введение

Колоректальный рак входит в число наиболее распространенных злокачественных новообразований в Соединенных Штатах и других высокоразвитых странах. При текущих показателях примерно у 6% в течение жизни разовьется это злокачественное новообразование. Приблизительно половина лиц, у которых диагностирован колоректальный рак, умрет от этого заболевания.

Риск развития колоректального рака может быть снижен путем скрининга, рекомендации по которому были выпущены несколькими крупными медицинскими сообществами.

Кроме того, был выявлен ряд защитных факторов, что вызвало интерес к первичной профилактике.

Среди защитных средств - аспирин и другие нестероидные противовоспалительные препараты (НПВП). Многочисленные и убедительные исследования показали, что НПВП подавляют колоректальный канцерогенез. Данные подтверждаются различными источниками, включая модели на животных, эпидемиологические данные, интервенционные исследования НПВП у пациентов с семейным полипозом, а также рандомизированные исследования аспирина и селективных ингибиторов циклооксигеназы-2 (ЦОГ-2) на людях.

Подтверждающие доказательства

Клиническое значение

Биологические основы

Резюме и рекомендации

Список литературы